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Influenza Virus Sialidase - A Drug Discovery Target by Mark Itzstein download in ePub, pdf, iPad

This cavity is formed by the loop and was therefore named the cavity. Be the first to write a review.

Crystallization and soaking

Recombinant baculovirus was prepared following the manufacturer's protocol Invitrogen. Neuraminidase enzymes are glycoside hydrolase enzymes that cleave the glycosidic linkages of neuraminic acids. Further rounds of refinement were performed using the phenix.

Crystallization conditions were screened using the sitting drop vapor diffusion method with commercial krorits Hampton Research. Disease outbreaks can occur relatively quickly as.

The enzymatic mechanism of influenza virus

The enzymatic mechanism of influenza virus sialidase has been studied by. Crystallization and soaking experiments.

Data collection, processing, and structure solution. Making and Breaking the Link. Covers all relevant aspects of anti-influenza virus drug discovery. The enzyme catalysis process has four steps.

Viral neuraminidase Influenza neuraminidase is a mushroom-shaped projection on the surface of the influenza virus. The composition of the polypeptide is a single chain of six conserved polar amino acids, followed by hydrophilic, variable amino acids. There are two major proteins on the surface of influenza virus particles. Neuraminidase enzymes are a large family, found in a range of organisms.